Psilocybin or Magic Mushrooms
Psilocybin is a psychedelic compound found in specific varieties of mushrooms, also known as “shrooms” or “magic mushrooms.” Psilocybin-containing mushrooms can be found in the wild in many parts of the world. They can be eaten fresh or dried, or brewed in a tea. Common sources include the P.cubensis mushroom and others of the genus Psilocybe. Nearly 100 species with varying levels of psilocybin have been identified.1
Psilocybin has been granted a breakthrough therapy designation by the FDA to be studied as a possible treatment for depression.2 Despite promising clinical application, psilocybin remains classified under Schedule I of the Controlled Substances Act and is illegal to possess or sell in the United States, though it has been decriminalized in some parts of the country, such as Oakland and Denver.
How Long Does Psilocybin Stay in Your System?
Urine: Up to 24 hours
Blood: Less than 24 hours
Hair: Up to 90 days
How Long Does It Take to Feel Effects?
After ingesting psilocybin-containing mushrooms, it will take 20 to 40 minutes to start feeling the effects. By then, psilocybin will have broken down into psilocin, which acts on serotonin receptors in the brain.3
The effects peak at about 90 minutes to two hours after ingestion. The bulk of the effects are felt during the first six hours,4 which matches the timing of when the metabolite psilocin enters the bloodstream to be eliminated through the kidneys.
Physical effects include nausea, yawning, headaches, and increased heart rate, blood pressure, and temperature.5 Mental effects include feeling relaxed and having introspective experiences that may feel spiritual, as well as unpleasant effects like nervousness, paranoia, and panic reactions.
Some studies and sources report that users can have long-term changes in personality, lasting for over a year.6
Some people who use psilocybin have reported flashback experiences long after taking mushrooms. Though typically not severe, there have been rare reports of people developing hallucinogen persisting perception disorder (HPPD) after taking mushrooms, and this requires further study